Ablation of 5-lipoxygenase mitigates pancreatic lesion development

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC), which continues to have a dismal prognosis, is associated with a pronounced fibro-inflammatory response. Inflammation in vivo can be mediated by 5-lipoxygenase (5LO), an enzyme that converts omega-6 fatty acids to eicosanoids, including leukotrien...

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Veröffentlicht in:J Surg Res
Hauptverfasser: Knab, Lawrence M., Schultz, Michelle, Principe, Daniel R., Mascarinas, Windel E., Gounaris, Elias, Munshi, Hidayatullah G., Grippo, Paul J., Bentrem, David J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4843112/
https://ncbi.nlm.nih.gov/pubmed/25454978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jss.2014.10.021
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