Zileuton, 5-Lipoxygenase Inhibitor, Acts as a Chemopreventive Agent in Intestinal Polyposis, by Modulating Polyp and Systemic Inflammation

PURPOSE: Leukotrienes and prostaglandins, products of arachidonic acid metabolism, sustain both systemic and lesion-localized inflammation. Tumor-associated Inflammation can also contribute to the pathogenesis of colon cancer. Patients with inflammatory bowel disease (IBD) have increased risk of dev...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Gounaris, Elias, Heiferman, Michael J., Heiferman, Jeffrey R., Shrivastav, Manisha, Vitello, Dominic, Blatner, Nichole R., Knab, Lawrence M., Phillips, Joseph D., Cheon, Eric C., Grippo, Paul J., Khazaie, Khashayarsha, Munshi, Hidayatullah G., Bentrem, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4351892/
https://ncbi.nlm.nih.gov/pubmed/25747113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0121402
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