Zileuton, 5-Lipoxygenase Inhibitor, Acts as a Chemopreventive Agent in Intestinal Polyposis, by Modulating Polyp and Systemic Inflammation

PURPOSE: Leukotrienes and prostaglandins, products of arachidonic acid metabolism, sustain both systemic and lesion-localized inflammation. Tumor-associated Inflammation can also contribute to the pathogenesis of colon cancer. Patients with inflammatory bowel disease (IBD) have increased risk of dev...

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Publicat a:PLoS One
Autors principals: Gounaris, Elias, Heiferman, Michael J., Heiferman, Jeffrey R., Shrivastav, Manisha, Vitello, Dominic, Blatner, Nichole R., Knab, Lawrence M., Phillips, Joseph D., Cheon, Eric C., Grippo, Paul J., Khazaie, Khashayarsha, Munshi, Hidayatullah G., Bentrem, David J.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4351892/
https://ncbi.nlm.nih.gov/pubmed/25747113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0121402
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