Characterization of mouse models of early pancreatic lesions induced by alcohol and chronic pancreatitis

OBJECTIVE: We describe the first mouse model of pancreatic intra-epithelial neoplasia (PanIN) lesions induced by alcohol in the presence and absence of chronic pancreatitis. METHODS: Pdx1-Cre; LSL-Kras (KC) mice were exposed to Lieber-DeCarli alcohol diet for 6 weeks with cerulein injections. PanIN...

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Detalhes bibliográficos
Publicado no:Pancreas
Main Authors: Xu, Shiping, Chheda, Chintan, Ouhaddi, Yassine, Benhaddou, Hajar, Bourhim, Mouloud, Grippo, Paul J., Principe, Daniel R., Mascariñas, Emman, DeCant, Brian, Tsukamoto, Hidekazu, Pandol, Stephen J., Edderkaoui, Mouad
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4503385/
https://ncbi.nlm.nih.gov/pubmed/26166469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MPA.0000000000000380
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