OneBac 2.0: Sf9 Cell Lines for Production of AAV5 Vectors with Enhanced Infectivity and Minimal Encapsidation of Foreign DNA

Scalable production of recombinant adeno-associated virus vectors (rAAV) in baculovirus-infected Sf9 cells yields high burst sizes but variable infectivity rates per packaged AAV vector genome depending on the chosen serotype. Infectivity rates are particularly low for rAAV5 vectors, based on the ge...

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Detalles Bibliográficos
Publicado en:Hum Gene Ther
Autores principales: Mietzsch, Mario, Casteleyn, Vincent, Weger, Stefan, Zolotukhin, Sergei, Heilbronn, Regine
Formato: Artigo
Lenguaje:Inglês
Publicado: Mary Ann Liebert, Inc. 2015
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4842952/
https://ncbi.nlm.nih.gov/pubmed/26134901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2015.050
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