OneBac 2.0: Sf9 Cell Lines for Production of AAV5 Vectors with Enhanced Infectivity and Minimal Encapsidation of Foreign DNA

Scalable production of recombinant adeno-associated virus vectors (rAAV) in baculovirus-infected Sf9 cells yields high burst sizes but variable infectivity rates per packaged AAV vector genome depending on the chosen serotype. Infectivity rates are particularly low for rAAV5 vectors, based on the ge...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Hum Gene Ther
Prif Awduron: Mietzsch, Mario, Casteleyn, Vincent, Weger, Stefan, Zolotukhin, Sergei, Heilbronn, Regine
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Mary Ann Liebert, Inc. 2015
Pynciau:
Research Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4842952/
https://ncbi.nlm.nih.gov/pubmed/26134901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2015.050
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