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Packaging of Human Chromosome 19-Specific Adeno-Associated Virus (AAV) Integration Sites in AAV Virions during AAV Wild-Type and Recombinant AAV Vector Production

Adeno-associated virus type 2 (AAV-2) establishes latency by site-specific integration into a unique locus on human chromosome 19, called AAVS1. During the development of a sensitive real-time PCR assay for site-specific integration, AAV-AAVS1 junctions were reproducibly detected in highly purified...

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Bibliografiske detaljer
Main Authors: Hüser, Daniela, Weger, Stefan, Heilbronn, Regine
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2003
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC152110/
https://ncbi.nlm.nih.gov/pubmed/12663794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.8.4881-4887.2003
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