Safety, pharmacokinetics and pharmacodynamics of the anti‐hepcidin Spiegelmer lexaptepid pegol in healthy subjects

BACKGROUND AND PURPOSE: Anaemia of chronic disease is characterized by impaired erythropoiesis due to functional iron deficiency, often caused by excessive hepcidin. Lexaptepid pegol, a pegylated structured l‐oligoribonucleotide, binds and inactivates hepcidin. EXPERIMENTAL APPROACH: We conducted a...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Boyce, M, Warrington, S, Cortezi, B, Zöllner, S, Vauléon, S, Swinkels, D W, Summo, L, Schwoebel, F, Riecke, K
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4842915/
https://ncbi.nlm.nih.gov/pubmed/26773325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13433
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