Chronic hepatitis C viral infection subverts vaccine‐induced T‐cell immunity in humans

Adenoviral vectors encoding hepatitis C virus (HCV) nonstructural (NS) proteins induce multispecific, high‐magnitude, durable CD4(+) and CD8(+) T‐cell responses in healthy volunteers. We assessed the capacity of these vaccines to induce functional HCV‐specific immune responses and determine T‐cell c...

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Detalhes bibliográficos
Publicado no:Hepatology
Main Authors: Kelly, Christabel, Swadling, Leo, Capone, Stefania, Brown, Anthony, Richardson, Rachel, Halliday, John, von Delft, Annette, Oo, Ye, Mutimer, David, Kurioka, Ayako, Hartnell, Felicity, Collier, Jane, Ammendola, Virginia, Sorbo, Mariarosaria Del, Grazioli, Fabiana, Esposito, Maria Luisa, Marco, Stefania Di, Siani, Loredana, Traboni, Cinzia, Hill, Adrian V.S., Colloca, Stefano, Nicosia, Alfredo, Cortese, Riccardo, Folgori, Antonella, Klenerman, Paul, Barnes, Eleanor
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Viral Hepatitis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4842008/
https://ncbi.nlm.nih.gov/pubmed/26474390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.28294
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