Epithelial Junction Opener Improves Oncolytic Adenovirus Therapy in Mouse Tumor Models

A central resistance mechanism in solid tumors is the maintenance of epithelial junctions between malignant cells that prevent drug penetration into the tumor. Human adenoviruses (Ads) have evolved mechanisms to breach epithelial barriers. For example, during Ad serotype 3 (Ad3) infection of epithel...

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Bibliografiset tiedot
Julkaisussa:Hum Gene Ther
Päätekijät: Yumul, Roma, Richter, Maximilian, Lu, Zhuo-Zhuang, Saydaminova, Kamola, Wang, Hongjie, Wang, Chung-Huei Katherine, Carter, Darrick, Lieber, André
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Mary Ann Liebert, Inc. 2016
Aiheet:
Research Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4840918/
https://ncbi.nlm.nih.gov/pubmed/26993072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2016.022
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