Preclinical safety and efficacy studies with an affinity-enhanced epithelial junction opener and PEGylated liposomal doxorubicin

A central treatment resistance mechanism in solid tumors is the maintenance of epithelial junctions between malignant cells that prevent drug penetration into the tumor. We have developed a small recombinant protein (JO-1) that triggers the transient opening of intercellular junctions and thus incre...

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Detalhes bibliográficos
Publicado no:Mol Ther Methods Clin Dev
Main Authors: Richter, Maximilian, Yumul, Roma, Wang, Hongjie, Saydaminova, Kamola, Ho, Martin, May, Drew, Baldessari, Audrey, Gough, Michael, Drescher, Charles, Urban, Nicole, Roffler, Steve, Zubieta, Chloé, Carter, Darrick, Fender, Pascal, Lieber, André
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4445001/
https://ncbi.nlm.nih.gov/pubmed/26029716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtm.2015.5
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