Epithelial Junction Opener Improves Oncolytic Adenovirus Therapy in Mouse Tumor Models

A central resistance mechanism in solid tumors is the maintenance of epithelial junctions between malignant cells that prevent drug penetration into the tumor. Human adenoviruses (Ads) have evolved mechanisms to breach epithelial barriers. For example, during Ad serotype 3 (Ad3) infection of epithel...

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Bibliographische Detailangaben
Veröffentlicht in:Hum Gene Ther
Hauptverfasser: Yumul, Roma, Richter, Maximilian, Lu, Zhuo-Zhuang, Saydaminova, Kamola, Wang, Hongjie, Wang, Chung-Huei Katherine, Carter, Darrick, Lieber, André
Format: Artigo
Sprache:Inglês
Veröffentlicht: Mary Ann Liebert, Inc. 2016
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4840918/
https://ncbi.nlm.nih.gov/pubmed/26993072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2016.022
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