Epithelial Junction Opener Improves Oncolytic Adenovirus Therapy in Mouse Tumor Models

A central resistance mechanism in solid tumors is the maintenance of epithelial junctions between malignant cells that prevent drug penetration into the tumor. Human adenoviruses (Ads) have evolved mechanisms to breach epithelial barriers. For example, during Ad serotype 3 (Ad3) infection of epithel...

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Detalhes bibliográficos
Publicado no:Hum Gene Ther
Main Authors: Yumul, Roma, Richter, Maximilian, Lu, Zhuo-Zhuang, Saydaminova, Kamola, Wang, Hongjie, Wang, Chung-Huei Katherine, Carter, Darrick, Lieber, André
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4840918/
https://ncbi.nlm.nih.gov/pubmed/26993072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2016.022
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