Epithelial Junction Opener Improves Oncolytic Adenovirus Therapy in Mouse Tumor Models

A central resistance mechanism in solid tumors is the maintenance of epithelial junctions between malignant cells that prevent drug penetration into the tumor. Human adenoviruses (Ads) have evolved mechanisms to breach epithelial barriers. For example, during Ad serotype 3 (Ad3) infection of epithel...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Hum Gene Ther
Main Authors: Yumul, Roma, Richter, Maximilian, Lu, Zhuo-Zhuang, Saydaminova, Kamola, Wang, Hongjie, Wang, Chung-Huei Katherine, Carter, Darrick, Lieber, André
Format: Artigo
Jezik:Inglês
Izdano: Mary Ann Liebert, Inc. 2016
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4840918/
https://ncbi.nlm.nih.gov/pubmed/26993072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2016.022
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