Epithelial Junction Opener Improves Oncolytic Adenovirus Therapy in Mouse Tumor Models

A central resistance mechanism in solid tumors is the maintenance of epithelial junctions between malignant cells that prevent drug penetration into the tumor. Human adenoviruses (Ads) have evolved mechanisms to breach epithelial barriers. For example, during Ad serotype 3 (Ad3) infection of epithel...

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Gepubliceerd in:Hum Gene Ther
Hoofdauteurs: Yumul, Roma, Richter, Maximilian, Lu, Zhuo-Zhuang, Saydaminova, Kamola, Wang, Hongjie, Wang, Chung-Huei Katherine, Carter, Darrick, Lieber, André
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Mary Ann Liebert, Inc. 2016
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Research Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4840918/
https://ncbi.nlm.nih.gov/pubmed/26993072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2016.022
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