Neuronal death induced by misfolded prion protein is due to NAD(+) depletion and can be relieved in vitro and in vivo by NAD(+) replenishment

The mechanisms of neuronal death in protein misfolding neurodegenerative diseases such as Alzheimer’s, Parkinson’s and prion diseases are poorly understood. We used a highly toxic misfolded prion protein (TPrP) model to understand neurotoxicity induced by prion protein misfolding. We show that abnor...

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Detalhes bibliográficos
Publicado no:Brain
Main Authors: Zhou, Minghai, Ottenberg, Gregory, Sferrazza, Gian Franco, Hubbs, Christopher, Fallahi, Mohammad, Rumbaugh, Gavin, Brantley, Alicia F., Lasmézas, Corinne I.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4840455/
https://ncbi.nlm.nih.gov/pubmed/25678560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awv002
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