Unique drug screening approach for prion diseases identifies tacrolimus and astemizole as antiprion agents

Prion diseases such as Creutzfeldt–Jakob disease (CJD) are incurable and rapidly fatal neurodegenerative diseases. Because prion protein (PrP) is necessary for prion replication but dispensable for the host, we developed the PrP–FRET-enabled high throughput assay (PrP–FEHTA) to screen for compounds...

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Bibliografiska uppgifter
Huvudupphovsmän: Karapetyan, Yervand Eduard, Sferrazza, Gian Franco, Zhou, Minghai, Ottenberg, Gregory, Spicer, Timothy, Chase, Peter, Fallahi, Mohammad, Hodder, Peter, Weissmann, Charles, Lasmézas, Corinne Ida
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2013
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3637718/
https://ncbi.nlm.nih.gov/pubmed/23576755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1303510110
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