Strain-Specific Role of RNAs in Prion Replication

Several lines of evidence suggest that various cofactors may be required for prion replication. PrP binds to polyanions, and RNAs were shown to promote the conversion of PrP(C) into PrP(Sc) in vitro. In the present study, we investigated strain-specific differences in RNA requirement during in vitro...

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Hlavní autoři: Saá, Paula, Sferrazza, Gian Franco, Ottenberg, Gregory, Oelschlegel, Anja M., Dorsey, Kerri, Lasmézas, Corinne I.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2012
Témata:
Prions
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457318/
https://ncbi.nlm.nih.gov/pubmed/22811520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01286-12
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