USP51 deubiquitylates H2AK13,15ub and regulates DNA damage response

Dynamic regulation of RNF168-mediated ubiquitylation of histone H2A Lys13,15 (H2AK13,15ub) at DNA double-strand breaks (DSBs) is crucial for preventing aberrant DNA repair and maintaining genome stability. However, it remains unclear which deubiquitylating enzyme (DUB) removes H2AK13,15ub. Here we s...

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Publicat a:Genes Dev
Autors principals: Wang, Zhiquan, Zhang, Honglian, Liu, Ji, Cheruiyot, Abigael, Lee, Jeong-Heon, Ordog, Tamas, Lou, Zhenkun, You, Zhongsheng, Zhang, Zhiguo
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2016
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4840300/
https://ncbi.nlm.nih.gov/pubmed/27083998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.271841.115
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