Selective Dual Inhibitors of the Cancer-Related Deubiquitylating Proteases USP7 and USP47

[Image: see text] Inhibitors of the cancer-related cysteine isopeptidase human ubiquitin-specific proteases 7 (USP7) and 47 (USP47) are considered to have potential as cancer therapeutics, owing to their ability to stabilize the tumor suppressor p53 and to decrease DNA polymerase β (Polβ), both of w...

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Detalhes bibliográficos
Main Authors: Weinstock, Joseph, Wu, Jian, Cao, Ping, Kingsbury, William D., McDermott, Jeffrey L., Kodrasov, Matthew P., McKelvey, Devin M., Suresh Kumar, K. G., Goldenberg, Seth J., Mattern, Michael R., Nicholson, Benjamin
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2012
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025646/
https://ncbi.nlm.nih.gov/pubmed/24900381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200276j
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