USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds

The Wnt signaling pathways play pivotal roles in carcinogenesis. Modulation of the cell-surface abundance of Wnt receptors is emerging as an important mechanism for regulating sensitivity to Wnt ligands. Endocytosis and degradation of the Wnt receptors Frizzled (Fzd) and lipoprotein-related protein...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Madan, Babita, Walker, Matthew P., Young, Robert, Quick, Laura, Orgel, Kelly A., Ryan, Meagan, Gupta, Priti, Henrich, Ian C., Ferrer, Marc, Marine, Shane, Roberts, Brian S., Arthur, William T., Berndt, Jason D., Oliveira, Andre M., Moon, Randall T., Virshup, David M., Chou, Margaret M., Major, Michael B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2016
Soggetti:
PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889410/
https://ncbi.nlm.nih.gov/pubmed/27162353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1605691113
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