USP4 Auto-Deubiquitylation Promotes Homologous Recombination

Repair of DNA double-strand breaks is crucial for maintaining genome integrity and is governed by post-translational modifications such as protein ubiquitylation. Here, we establish that the deubiquitylating enzyme USP4 promotes DNA-end resection and DNA repair by homologous recombination. We also r...

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Udgivet i:Mol Cell
Main Authors: Wijnhoven, Paul, Konietzny, Rebecca, Blackford, Andrew N., Travers, Jonathan, Kessler, Benedikt M., Nishi, Ryotaro, Jackson, Stephen P.
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4643306/
https://ncbi.nlm.nih.gov/pubmed/26455393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.09.019
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