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USP4 Auto-Deubiquitylation Promotes Homologous Recombination
Repair of DNA double-strand breaks is crucial for maintaining genome integrity and is governed by post-translational modifications such as protein ubiquitylation. Here, we establish that the deubiquitylating enzyme USP4 promotes DNA-end resection and DNA repair by homologous recombination. We also r...
שמור ב:
| הוצא לאור ב: | Mol Cell |
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| Main Authors: | , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Cell Press
2015
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4643306/ https://ncbi.nlm.nih.gov/pubmed/26455393 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.09.019 |
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