The deubiquitylating enzyme USP15 regulates homologous recombination repair and cancer cell response to PARP inhibitors

Poly-(ADP-ribose) polymerase inhibitors (PARPi) selectively kill breast and ovarian cancers with defects in homologous recombination (HR) caused by BRCA1/2 mutations. There is also clinical evidence for the utility of PARPi in breast and ovarian cancers without BRCA mutations, but the underlying mec...

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Udgivet i:Nat Commun
Main Authors: Peng, Yihan, Liao, Qingchao, Tan, Wei, Peng, Changmin, Hu, Zhaohua, Chen, Yali, Li, Zhuqing, Li, Jing, Zhen, Bei, Zhu, Wenge, Li, Xiangpan, Yao, Yi, Song, Qibin, Liu, Chengsheng, Qi, Xiangdong, He, Fuchu, Pei, Huadong
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6420636/
https://ncbi.nlm.nih.gov/pubmed/30874560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09232-8
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