USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds

The Wnt signaling pathways play pivotal roles in carcinogenesis. Modulation of the cell-surface abundance of Wnt receptors is emerging as an important mechanism for regulating sensitivity to Wnt ligands. Endocytosis and degradation of the Wnt receptors Frizzled (Fzd) and lipoprotein-related protein...

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發表在:Proc Natl Acad Sci U S A
Main Authors: Madan, Babita, Walker, Matthew P., Young, Robert, Quick, Laura, Orgel, Kelly A., Ryan, Meagan, Gupta, Priti, Henrich, Ian C., Ferrer, Marc, Marine, Shane, Roberts, Brian S., Arthur, William T., Berndt, Jason D., Oliveira, Andre M., Moon, Randall T., Virshup, David M., Chou, Margaret M., Major, Michael B.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2016
主題:
PNAS Plus
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889410/
https://ncbi.nlm.nih.gov/pubmed/27162353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1605691113
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