RPA Interacts with HIRA and Regulates H3.3 Deposition at Gene Regulatory Elements in Mammalian Cells

The histone chaperone HIRA is involved in depositing histone variant H3.3 into distinct genic regions including promoters, enhancers and gene bodies. However, how HIRA deposits H3.3 to these regions remains elusive. Through an shRNA screening, we identified single-stranded DNA binding protein RPA as...

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Publicado no:Mol Cell
Main Authors: Zhang, Honglian, Gan, Haiyun, Wang, Zhiquan, Lee, Jeong-Heon, Zhou, Hui, Ordog, Tamas, Wold, Marc S., Ljungman, Mats, Zhang, Zhiguo
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5460635/
https://ncbi.nlm.nih.gov/pubmed/28107649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.11.030
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