Determining the frequency of pathogenic germline variants from exome sequencing in patients with castrate-resistant prostate cancer

OBJECTIVES: To determine the frequency of pathogenic inherited mutations in 157 select genes from patients with metastatic castrate-resistant prostate cancer (mCRPC). DESIGN: Observational. SETTING: Multisite US-based cohort. PARTICIPANTS: Seventy-one adult male patients with histological confirmati...

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Publicat a:BMJ Open
Autors principals: Hart, Steven N, Ellingson, Marissa S, Schahl, Kim, Vedell, Peter T, Carlson, Rachel E, Sinnwell, Jason P, Barman, Poulami, Sicotte, Hugues, Eckel-Passow, Jeanette E, Wang, Liguo, Kalari, Krishna R, Qin, Rui, Kruisselbrink, Teresa M, Jimenez, Rafael E, Bryce, Alan H, Tan, Winston, Weinshilboum, Richard, Wang, Liewei, Kohli, Manish
Format: Artigo
Idioma:Inglês
Publicat: BMJ Publishing Group 2016
Matèries:
Genetics and Genomics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4838679/
https://ncbi.nlm.nih.gov/pubmed/27084275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bmjopen-2015-010332
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