Exome sequencing reveals frequent deleterious germline variants in cancer susceptibility genes in women with invasive breast cancer undergoing neoadjuvant chemotherapy

When sequencing blood and tumor samples to identify targetable somatic variants for cancer therapy, clinically relevant germline variants may be uncovered. We evaluated the prevalence of deleterious germline variants in cancer susceptibility genes in women with breast cancer referred for neoadjuvant...

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Detalhes bibliográficos
Publicado no:Breast Cancer Res Treat
Main Authors: Ellingson, Marissa S., Hart, Steven N., Kalari, Krishna R., Suman, Vera, Schahl, Kimberly A., Dockter, Travis J., Felten, Sara J., Sinnwell, Jason P., Thompson, Kevin J., Tang, Xiaojia, Vedell, Peter T., Barman, Poulami, Sicotte, Hugues, Eckel-Passow, Jeanette E., Northfelt, Donald W., Gray, Richard J., McLaughlin, Sarah A., Moreno-Aspitia, Alvaro, Ingle, James N., Moyer, Ann M., Visscher, Daniel W., Jones, Katie, Conners, Amy, McDonough, Michelle, Wieben, Eric D., Wang, Liewei, Weinshilboum, Richard, Boughey, Judy C., Goetz, Matthew P.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2015
Assuntos:
Epidemiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4559569/
https://ncbi.nlm.nih.gov/pubmed/26296701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-015-3545-6
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