Exome sequencing reveals frequent deleterious germline variants in cancer susceptibility genes in women with invasive breast cancer undergoing neoadjuvant chemotherapy

When sequencing blood and tumor samples to identify targetable somatic variants for cancer therapy, clinically relevant germline variants may be uncovered. We evaluated the prevalence of deleterious germline variants in cancer susceptibility genes in women with breast cancer referred for neoadjuvant...

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Publicat a:Breast Cancer Res Treat
Autors principals: Ellingson, Marissa S., Hart, Steven N., Kalari, Krishna R., Suman, Vera, Schahl, Kimberly A., Dockter, Travis J., Felten, Sara J., Sinnwell, Jason P., Thompson, Kevin J., Tang, Xiaojia, Vedell, Peter T., Barman, Poulami, Sicotte, Hugues, Eckel-Passow, Jeanette E., Northfelt, Donald W., Gray, Richard J., McLaughlin, Sarah A., Moreno-Aspitia, Alvaro, Ingle, James N., Moyer, Ann M., Visscher, Daniel W., Jones, Katie, Conners, Amy, McDonough, Michelle, Wieben, Eric D., Wang, Liewei, Weinshilboum, Richard, Boughey, Judy C., Goetz, Matthew P.
Format: Artigo
Idioma:Inglês
Publicat: Springer US 2015
Matèries:
Epidemiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4559569/
https://ncbi.nlm.nih.gov/pubmed/26296701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-015-3545-6
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