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Exploring the intracellular pharmacokinetics of the 5‐fluorouracil nucleotides during capecitabine treatment
AIM: Three intracellularly formed metabolites are responsible for the antineoplastic effect of capecitabine: 5‐fluorouridine 5′‐triphosphate (FUTP), 5‐fluoro‐2′‐deoxyuridine 5′‐triphosphate (FdUTP), and 5‐fluoro‐2′‐deoxyuridine 5′‐monophosphate (FdUMP). The objective of this study was to explore the...
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| Publié dans: | Br J Clin Pharmacol |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
John Wiley and Sons Inc.
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4834600/ https://ncbi.nlm.nih.gov/pubmed/26718616 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12877 |
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