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Intracellular Pharmacokinetics of Pyrimidine Analogues used in Oncology and the Correlation with Drug Action

Pyrimidine analogues can be considered as prodrugs, like their natural counterparts, they have to be activated within the cell. The intracellular activation involves several metabolic steps including sequential phosphorylation to its monophosphate, diphosphate and triphosphate. The intracellularly f...

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Bibliografiske detaljer
Udgivet i:Clin Pharmacokinet
Main Authors: Derissen, Ellen J. B., Beijnen, Jos H.
Format: Artigo
Sprog:Inglês
Udgivet: Springer International Publishing 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7717039/
https://ncbi.nlm.nih.gov/pubmed/33064276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-020-00934-7
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