Intracellular pharmacokinetics of gemcitabine, its deaminated metabolite 2′,2′‐difluorodeoxyuridine and their nucleotides

AIMS: Gemcitabine (2′,2′‐difluoro‐2′‐deoxycytidine; dFdC) is a prodrug that has to be phosphorylated within the tumour cell to become active. Intracellularly formed gemcitabine diphosphate (dFdCDP) and triphosphate (dFdCTP) are considered responsible for the antineoplastic effects of gemcitabine. Ho...

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Bibliografiska uppgifter
I publikationen:Br J Clin Pharmacol
Huvudupphovsmän: Derissen, Ellen J. B., Huitema, Alwin D. R., Rosing, Hilde, Schellens, Jan H. M., Beijnen, Jos H.
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2018
Ämnen:
Original Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5980516/
https://ncbi.nlm.nih.gov/pubmed/29451684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13557
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