Incorporation of concentration data below the limit of quantification in population pharmacokinetic analyses

Handling of data below the lower limit of quantification (LLOQ), below the limit of quantification (BLOQ) in population pharmacokinetic (PopPK) analyses is important for reducing bias and imprecision in parameter estimation. We aimed to evaluate whether using the concentration data below the LLOQ ha...

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Bibliografiske detaljer
Udgivet i:Pharmacol Res Perspect
Main Authors: Keizer, Ron J, Jansen, Robert S, Rosing, Hilde, Thijssen, Bas, Beijnen, Jos H, Schellens, Jan H M, Huitema, Alwin D R
Format: Artigo
Sprog:Inglês
Udgivet: BlackWell Publishing Ltd 2015
Fag:
Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4448983/
https://ncbi.nlm.nih.gov/pubmed/26038706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.131
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