Incorporation of concentration data below the limit of quantification in population pharmacokinetic analyses

Handling of data below the lower limit of quantification (LLOQ), below the limit of quantification (BLOQ) in population pharmacokinetic (PopPK) analyses is important for reducing bias and imprecision in parameter estimation. We aimed to evaluate whether using the concentration data below the LLOQ ha...

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Bibliographic Details
Published in:Pharmacol Res Perspect
Main Authors: Keizer, Ron J, Jansen, Robert S, Rosing, Hilde, Thijssen, Bas, Beijnen, Jos H, Schellens, Jan H M, Huitema, Alwin D R
Format: Artigo
Language:Inglês
Published: BlackWell Publishing Ltd 2015
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4448983/
https://ncbi.nlm.nih.gov/pubmed/26038706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.131
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