Exploring the intracellular pharmacokinetics of the 5‐fluorouracil nucleotides during capecitabine treatment

AIM: Three intracellularly formed metabolites are responsible for the antineoplastic effect of capecitabine: 5‐fluorouridine 5′‐triphosphate (FUTP), 5‐fluoro‐2′‐deoxyuridine 5′‐triphosphate (FdUTP), and 5‐fluoro‐2′‐deoxyuridine 5′‐monophosphate (FdUMP). The objective of this study was to explore the...

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Dettagli Bibliografici
Pubblicato in:Br J Clin Pharmacol
Autori principali: Derissen, Ellen J. B., Jacobs, Bart A. W., Huitema, Alwin D. R., Rosing, Hilde, Schellens, Jan H. M., Beijnen, Jos H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2016
Soggetti:
Pharmacokinetics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4834600/
https://ncbi.nlm.nih.gov/pubmed/26718616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12877
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