SGK kinase activity in multiple myeloma cells protects against ER stress apoptosis via a SEK-dependent mechanism

To assess the role of the SGK kinase in multiple myeloma (MM), we ectopically expressed wild type or a phosphomimetic version of SGK into MM cell lines. These cells were specifically resistant to the ER stress inducers tunicamycin, thapsigargin and bortezomib. In contrast, there was no alteration of...

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Veröffentlicht in:Mol Cancer Res
Hauptverfasser: Hoang, Bao, Shi, Yijiang, Frost, Patrick, Mysore, Veena, Bardeleben, Carolyne, Lichtenstein, Alan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4834283/
https://ncbi.nlm.nih.gov/pubmed/26869290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-15-0422
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