Metabolomics identifies pyrimidine starvation as the mechanism of 5-aminoimidazole-4-carboxamide-1-β-riboside (AICAr) induced apoptosis in multiple myeloma cells

To investigate the mechanism by which AICAr induces apoptosis in multiple myeloma (MM) cells, we performed an unbiased metabolomics screen. AICAr had selective effects on nucleotide metabolism, resulting in an increase in purine metabolites and a decrease in pyrimidine metabolites. The most striking...

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Detalhes bibliográficos
Main Authors: Bardeleben, Carolyne, Sharma, Sanjai, Reeve, Joseph R., Bassilian, Sara, Frost, Patrick, Hoang, Bao, Shi, Yijiang, Lichtenstein, Alan
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3707969/
https://ncbi.nlm.nih.gov/pubmed/23585020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-12-1042
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