Solid-Phase Synthesis of a New Diphosphate 5-Aminoimidazole-4-carboxamide Riboside (AICAR) Derivative and Studies toward Cyclic AICAR Diphosphate Ribose

The solid-phase synthesis of the first example of a new diphosphate AICAR derivative is reported. The new substance is characterized by the presence of a 5'-phosphate group while a second phosphate moiety is installed on a 5-hydroxypentyl chain attached to the 4-N-position of AICAR. Cyclization...

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Bibliographic Details
Published in:Molecules
Main Authors: D’Errico, Stefano, Oliviero, Giorgia, Borbone, Nicola, Amato, Jussara, Piccialli, Vincenzo, Varra, Michela, Mayol, Luciano, Piccialli, Gennaro
Format: Artigo
Language:Inglês
Published: MDPI 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6264535/
https://ncbi.nlm.nih.gov/pubmed/21937970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules16098110
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