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SGK kinase activity in multiple myeloma cells protects against ER stress apoptosis via a SEK-dependent mechanism
To assess the role of the SGK kinase in multiple myeloma (MM), we ectopically expressed wild type or a phosphomimetic version of SGK into MM cell lines. These cells were specifically resistant to the ER stress inducers tunicamycin, thapsigargin and bortezomib. In contrast, there was no alteration of...
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| Publicado no: | Mol Cancer Res |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4834283/ https://ncbi.nlm.nih.gov/pubmed/26869290 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-15-0422 |
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