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Mammalian Target of Rapamycin Inhibitors Induce Tumor Cell Apoptosis In Vivo Primarily by Inhibiting VEGF Expression and Angiogenesis

We found that rapalog mTOR inhibitors induce G1 arrest in the PTEN-null HS Sultan B-cell lymphoma line in vitro, but that administration of rapalogs in a HS Sultan xenograft model resulted in significant apoptosis, and that this correlated with induction of hypoxia and inhibition of neoangiogenesis...

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Detalhes bibliográficos
Main Authors: Frost, Patrick, Berlanger, Eileen, Mysore, Veena, Hoang, Bao, Shi, YiJiang, Gera, Joseph, Lichtenstein, Alan
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3603547/
https://ncbi.nlm.nih.gov/pubmed/23533410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/897025
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