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MNK KINASES FACILITATE C-MYC IRES ACTIVITY IN RAPAMYCIN-TREATED MULTIPLE MYELOMA CELLS
When mTOR inhibitor rapalogs prevent cap-dependent translation of cell cycle proteins like cmyc, continuing tumor cell growth depends on cap-independent translation, which is mediated by internal ribosome entry sites (IRESes) located in the 5′UTR of transcripts. To investigate if rapalog-induced act...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3401333/ https://ncbi.nlm.nih.gov/pubmed/22370634 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.43 |
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