The PP242 Mammalian Target of Rapamycin (mTOR) Inhibitor Activates Extracellular Signal-regulated Kinase (ERK) in Multiple Myeloma Cells via a Target of Rapamycin Complex 1 (TORC1)/ Eukaryotic Translation Initiation Factor 4E (eIF-4E)/RAF Pathway and Activation Is a Mechanism of Resistance

Activation of PI3-K-AKT and ERK pathways is a complication of mTOR inhibitor therapy. Newer mTOR inhibitors (like pp242) can overcome feedback activation of AKT in multiple myeloma (MM) cells. We, thus, studied if feedback activation of ERK is still a complication of therapy with such drugs in this...

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Bibliografiske detaljer
Main Authors: Hoang, Bao, Benavides, Angelica, Shi, Yijiang, Yang, Yonghui, Frost, Patrick, Gera, Joseph, Lichtenstein, Alan
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3381142/
https://ncbi.nlm.nih.gov/pubmed/22556409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.304626
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