Targeting TORC2 in multiple myeloma with a new mTOR kinase inhibitor

Although preclinical work with rapalogs suggests potential in treatment of multiple myeloma (MM), they have been less successful clinically. These drugs allostearically inhibit the mammalian target of rapamycin kinase primarily curtailing activity of the target of rapamycin complex (TORC)1. To asses...

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Main Authors: Hoang, Bao, Frost, Patrick, Shi, Yijiang, Belanger, Eileen, Benavides, Angelica, Pezeshkpour, Gholam, Cappia, Susanna, Guglielmelli, Tommasina, Gera, Joseph, Lichtenstein, Alan
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2010
Assuntos:
Lymphoid Neoplasia
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2996116/
https://ncbi.nlm.nih.gov/pubmed/20686120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-05-285726
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