CYTOTOXIC PROPERTIES OF A DEPTOR-mTOR INHIBITOR IN MULTIPLE MYELOMA CELLS

DEPTOR is a 48kDa protein that binds to mTOR and inhibits this kinase in TORC1 and TORC2 complexes. Over-expression of DEPTOR specifically occurs in a model of multiple myeloma (MM). Its silencing in MM cells is sufficient to induce cytotoxicity, suggesting DEPTOR is a potential therapeutic target....

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Detaylı Bibliyografya
Yayımlandı:Cancer Res
Asıl Yazarlar: Shi, Yijiang, Daniels-Wells, Tracy R., Frost, Patrick, Lee, Jihye, Finn, Richard S., Bardeleben, Carolyne, Penichet, Manuel L., Jung, Michael E., Gera, Joseph, Lichtenstein, Alan
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5100807/
https://ncbi.nlm.nih.gov/pubmed/27530328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-1019
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