DEPTOR is linked to a TORC1-p21 survival proliferation pathway in multiple myeloma cells

We investigated the mechanism by which gene silencing of the mTOR inhibitor, DEPTOR, induces cytoreductive effects on multiple myeloma (MM) cells. DEPTOR knockdown resulted in anti-MM effects in several MM cell lines. Using an inducible shRNA to silence DEPTOR, 8226 MM cells underwent TORC1 activati...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Genes Cancer
Prif Awduron: Yang, Yonghui, Bardeleben, Carolyne, Frost, Patrick, Hoang, Bao, Shi, Yijiang, Finn, Richard, Gera, Joseph, Lichtenstein, Alan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Impact Journals LLC 2014
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4279438/
https://ncbi.nlm.nih.gov/pubmed/25568666
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