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THERAPEUTIC POTENTIAL OF TARGETING IRES-DEPENDENT c-MYC TRANSLATION IN MULTIPLE MYELOMA CELLS DURING ER STRESS
Protein translation is inhibited by the unfolded protein response (UPR)-induced eIF-2α phosphorylation to protect against endoplasmic reticulum (ER) stress. In addition, we found additional inhibition of protein translation due to diminished mTORC1 activity in ER-stressed multiple myeloma (MM) cells...
שמור ב:
| הוצא לאור ב: | Oncogene |
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| Main Authors: | , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2015
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5104155/ https://ncbi.nlm.nih.gov/pubmed/25961916 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.156 |
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