THERAPEUTIC POTENTIAL OF TARGETING IRES-DEPENDENT c-MYC TRANSLATION IN MULTIPLE MYELOMA CELLS DURING ER STRESS

Protein translation is inhibited by the unfolded protein response (UPR)-induced eIF-2α phosphorylation to protect against endoplasmic reticulum (ER) stress. In addition, we found additional inhibition of protein translation due to diminished mTORC1 activity in ER-stressed multiple myeloma (MM) cells...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Shi, Yijiang, Yang, Yonghui, Hoang, Bao, Bardeleben, Carolyne, Holmes, Brent, Gera, Joseph, Lichtenstein, Alan
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5104155/
https://ncbi.nlm.nih.gov/pubmed/25961916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.156
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