Specific blockade of Rictor-mTOR association inhibits mTORC2 activity and is cytotoxic in glioblastoma

A small molecule which specifically blocks the interaction of Rictor and mTOR was identified utilizing a high-throughput yeast two-hybrid screen and evaluated as a potential inhibitor of mTORC2 activity in glioblastoma multiforme (GBM). In vitro, CID613034 inhibited mTORC2 kinase activity at submicr...

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Udgivet i:PLoS One
Main Authors: Benavides-Serrato, Angelica, Lee, Jihye, Holmes, Brent, Landon, Kenna A., Bashir, Tariq, Jung, Michael E., Lichtenstein, Alan, Gera, Joseph
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409528/
https://ncbi.nlm.nih.gov/pubmed/28453552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0176599
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