Mechanistic Target of Rapamycin (mTOR) Inhibition Synergizes with Reduced Internal Ribosome Entry Site (IRES)-mediated Translation of Cyclin D1 and c-MYC mRNAs to Treat Glioblastoma

Our previous work has demonstrated an intrinsic mRNA-specific protein synthesis salvage pathway operative in glioblastoma (GBM) tumor cells that is resistant to mechanistic target of rapamycin (mTOR) inhibitors. The activation of this internal ribosome entry site (IRES)-dependent mRNA translation in...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Holmes, Brent, Lee, Jihye, Landon, Kenna A., Benavides-Serrato, Angelica, Bashir, Tariq, Jung, Michael E., Lichtenstein, Alan, Gera, Joseph
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2016
Soggetti:
Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933173/
https://ncbi.nlm.nih.gov/pubmed/27226604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.726927
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