mTORC2/AKT/HSF1/HuR constitute a feed-forward loop regulating Rictor expression and tumor growth in glioblastoma

Overexpression of Rictor has been demonstrated to result in increased mTORC2 nucleation and activity leading to tumor growth and increased invasive characteristics in glioblastoma multiforme (GBM). However the mechanisms regulating Rictor expression in these tumors is not clearly understood. In this...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Holmes, Brent, Benavides-Serrato, Angelica, Freeman, Ryan S., Landon, Kenna A., Bashir, Tariq, Nishimura, Robert N., Gera, Joseph
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5805585/
https://ncbi.nlm.nih.gov/pubmed/29059166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2017.360
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