mTORC2/AKT/HSF1/HuR constitute a feed-forward loop regulating Rictor expression and tumor growth in glioblastoma

Overexpression of Rictor has been demonstrated to result in increased mTORC2 nucleation and activity leading to tumor growth and increased invasive characteristics in glioblastoma multiforme (GBM). However the mechanisms regulating Rictor expression in these tumors is not clearly understood. In this...

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Veröffentlicht in:Oncogene
Hauptverfasser: Holmes, Brent, Benavides-Serrato, Angelica, Freeman, Ryan S., Landon, Kenna A., Bashir, Tariq, Nishimura, Robert N., Gera, Joseph
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5805585/
https://ncbi.nlm.nih.gov/pubmed/29059166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2017.360
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