Phosphorylation of the Hippo Pathway Component AMOTL2 by the mTORC2 Kinase Promotes YAP Signaling, Resulting in Enhanced Glioblastoma Growth and Invasiveness

The mechanistic target of rapamycin (mTOR) and Hippo signaling pathways are two major signaling cascades that coordinately regulate cell growth and proliferation. Dysregulation of these pathways plays a critical role in gliomagenesis. Recent reports have provided evidence of cross-talk between the m...

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Библиографические подробности
Опубликовано в: :J Biol Chem
Главные авторы: Artinian, Nicholas, Cloninger, Cheri, Holmes, Brent, Benavides-Serrato, Angelica, Bashir, Tariq, Gera, Joseph
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2015
Предметы:
Signal Transduction
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4528104/
https://ncbi.nlm.nih.gov/pubmed/25998128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.656587
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