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Phosphorylation of the Hippo Pathway Component AMOTL2 by the mTORC2 Kinase Promotes YAP Signaling, Resulting in Enhanced Glioblastoma Growth and Invasiveness

The mechanistic target of rapamycin (mTOR) and Hippo signaling pathways are two major signaling cascades that coordinately regulate cell growth and proliferation. Dysregulation of these pathways plays a critical role in gliomagenesis. Recent reports have provided evidence of cross-talk between the m...

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Bibliografski detalji
Izdano u:J Biol Chem
Glavni autori: Artinian, Nicholas, Cloninger, Cheri, Holmes, Brent, Benavides-Serrato, Angelica, Bashir, Tariq, Gera, Joseph
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4528104/
https://ncbi.nlm.nih.gov/pubmed/25998128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.656587
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