Phosphorylation of the Hippo Pathway Component AMOTL2 by the mTORC2 Kinase Promotes YAP Signaling, Resulting in Enhanced Glioblastoma Growth and Invasiveness

The mechanistic target of rapamycin (mTOR) and Hippo signaling pathways are two major signaling cascades that coordinately regulate cell growth and proliferation. Dysregulation of these pathways plays a critical role in gliomagenesis. Recent reports have provided evidence of cross-talk between the m...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Artinian, Nicholas, Cloninger, Cheri, Holmes, Brent, Benavides-Serrato, Angelica, Bashir, Tariq, Gera, Joseph
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2015
Ämnen:
Signal Transduction
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4528104/
https://ncbi.nlm.nih.gov/pubmed/25998128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.656587
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