Inhibition of SAPK2/p38 enhances sensitivity to mTORC1 inhibition by blocking IRES-mediated translation initiation in glioblastoma

A variety of mechanisms confer hypersensitivity of tumor cells to the macrolide rapamycin, the prototypic mTORC1 inhibitor. Several studies have demonstrated that the status of the AKT kinase plays a critical role in determining hypersensitivity. Cancer cells in which AKT activity is elevated are ex...

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Hlavní autoři: Cloninger, Cheri, Bernath, Andrew, Bashir, Tariq, Holmes, Brent, Artinian, Nicholas, Ruegg, Teresa, Anderson, Lauren, Masri, Janine, Lichtenstein, Alan, Gera, Joseph
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3237929/
https://ncbi.nlm.nih.gov/pubmed/21911485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-11-0478
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