Phosphomimetic Substitution of Heterogeneous Nuclear Ribonucleoprotein A1 at Serine 199 Abolishes AKT-dependent Internal Ribosome Entry Site-transacting Factor (ITAF) Function via Effects on Strand Annealing and Results in Mammalian Target of Rapamycin Complex 1 (mTORC1) Inhibitor Sensitivity

The relative activity of the AKT kinase has been demonstrated to be a major determinant of sensitivity of tumor cells to mammalian target of rapamycin (mTOR) complex 1 inhibitors. Our previous studies have shown that the multifunctional RNA-binding protein heterogeneous nuclear ribonucleoprotein (hn...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Martin, Jheralyn, Masri, Janine, Cloninger, Cheri, Holmes, Brent, Artinian, Nicholas, Funk, Alexander, Ruegg, Teresa, Anderson, Lauren, Bashir, Tariq, Bernath, Andrew, Lichtenstein, Alan, Gera, Joseph
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2011
נושאים:
Signal Transduction
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3091246/
https://ncbi.nlm.nih.gov/pubmed/21454539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.205096
תגים: הוספת תג
אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!

פריטים דומים