Phosphomimetic Substitution of Heterogeneous Nuclear Ribonucleoprotein A1 at Serine 199 Abolishes AKT-dependent Internal Ribosome Entry Site-transacting Factor (ITAF) Function via Effects on Strand Annealing and Results in Mammalian Target of Rapamycin Complex 1 (mTORC1) Inhibitor Sensitivity

The relative activity of the AKT kinase has been demonstrated to be a major determinant of sensitivity of tumor cells to mammalian target of rapamycin (mTOR) complex 1 inhibitors. Our previous studies have shown that the multifunctional RNA-binding protein heterogeneous nuclear ribonucleoprotein (hn...

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Autores principales: Martin, Jheralyn, Masri, Janine, Cloninger, Cheri, Holmes, Brent, Artinian, Nicholas, Funk, Alexander, Ruegg, Teresa, Anderson, Lauren, Bashir, Tariq, Bernath, Andrew, Lichtenstein, Alan, Gera, Joseph
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3091246/
https://ncbi.nlm.nih.gov/pubmed/21454539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.205096
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