Heterogeneous Nuclear Ribonucleoprotein A1 Regulates Cyclin D1 and c-myc Internal Ribosome Entry Site Function through Akt Signaling

The translation of the cyclin D1 and c-myc mRNAs occurs via internal ribosome entry site (IRES)-mediated initiation under conditions of reduced eIF-4F complex formation and Akt activity. Here we identify hnRNP A1 as an IRES trans-acting factor that regulates cyclin D1 and c-myc IRES activity, depend...

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Detalhes bibliográficos
Main Authors: Jo, Oak D., Martin, Jheralyn, Bernath, Andrew, Masri, Janine, Lichtenstein, Alan, Gera, Joseph
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2516998/
https://ncbi.nlm.nih.gov/pubmed/18562319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801185200
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